Intestinal Fibrosis

The EpiIntestinal full thickness (SMI-FT) tissue model is useful for testing candidate drugs or biologics to treat diseases that are characterized by inflammation of the small intestine.

The Model

EpiIntestinal Full Thickness (SMI-FT) is a 3D reconstructed tissue model produced from normal, human cell-derived small intestine epithelial cells and fibroblasts. The highly differentiated tissue model is produced at the air-liquid-interface (ALI) in easy-to-handle tissue culture inserts. Structural analysis of the tissue model demonstrates columnar shaped basal cells and Kerckring folds. Ultrastructurally, EpiIntestinal exhibits brush borders, functional tight junctions and mucous secreting granules, similar to in vivo tissue.

 

Fig 1A

Transmission electron micrograph (TEM) of in vitro EpiIntestinal (A) and Explant tissues (B) showing Brush borders (situated at the luminal pole of the enterocyte) and tight junctions. Brush border – provides digestive and absorption surface; site for enzymes & transporters.

The Method

Picture11

SMI-100-FT Tissue Model  SMI-100-FT Tissue Model – Wounded

Picture12

SMI-100-FT Tissue model stained for ECM protein – Fibronectin (red) and DAPI nuclear stain (blue).

For more information, view the EpiIntestinal  and References.

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